Gu He Selected Research

BL-EI001

2/2017	Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells.
3/2015	Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer.

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Gu He Research Topics

Disease

44	Neoplasms (Cancer) 01/2022 - 06/2009
9	Breast Neoplasms (Breast Cancer) 01/2018 - 10/2014
6	Carcinogenesis 01/2021 - 09/2017
5	Inflammation (Inflammations) 01/2022 - 01/2019
5	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 09/2010
4	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 12/2017
3	Neoplasm Metastasis (Metastasis) 01/2021 - 11/2012
3	Arthritis (Polyarthritis) 01/2020 - 03/2016
3	Melanoma (Melanoma, Malignant) 12/2019 - 09/2014
2	Renal Cell Carcinoma (Grawitz Tumor) 12/2021 - 01/2019
2	Rosacea (Acne Rosacea) 04/2021 - 01/2019
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2020 - 01/2019
2	Acne Vulgaris 07/2019 - 01/2019
2	Nasopharyngeal Carcinoma 01/2019 - 09/2017
2	Carcinoma (Carcinomatosis) 01/2019 - 05/2013
2	Bacterial Infections (Bacterial Infection) 11/2018 - 01/2017
2	Infections 11/2018 - 09/2014
2	Ovarian Neoplasms (Ovarian Cancer) 12/2013 - 05/2013
1	Pathologic Processes 01/2022
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Triple Negative Breast Neoplasms 12/2021
1	Adenocarcinoma 05/2021
1	Glioblastoma (Glioblastoma Multiforme) 08/2020
1	Ischemia 07/2020
1	Myocardial Infarction 07/2020
1	Cardiotoxicity 01/2020
1	Rheumatic Diseases (Rheumatism) 01/2020
1	Contusions 01/2020
1	Chronic Disease (Chronic Diseases) 01/2020

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2015
12	Pharmaceutical PreparationsIBA 01/2022 - 06/2009
12	Biological ProductsIBA 05/2021 - 03/2015
6	MicellesIBA 11/2018 - 04/2011
4	Phosphotransferases (Kinase)IBA 07/2020 - 01/2018
4	CholesterolIBA 11/2018 - 04/2011
3	Small Interfering RNA (siRNA)IBA 12/2021 - 12/2013
3	Competitive Endogenous RNAIBA 04/2021 - 09/2017
3	Long Noncoding RNAIBA 04/2021 - 09/2017
3	SpirooxindolesIBA 08/2020 - 08/2015
3	Therapeutic UsesIBA 01/2019 - 10/2014
3	Peptides (Polypeptides)IBA 05/2018 - 10/2016
3	Amino Acids FDA Link 01/2018 - 01/2014
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2017 - 10/2014
3	Liposomes (Liposome)IBA 01/2017 - 09/2010
2	Drug CombinationsIBA 01/2022 - 01/2021
2	Messenger RNA (mRNA)IBA 04/2021 - 01/2019
2	RNA (Ribonucleic Acid)IBA 04/2021 - 01/2020
2	Elongation Factor 2 KinaseIBA 01/2021 - 01/2018
2	pyrimidineIBA 01/2020 - 01/2019
2	Protein Kinases (Protein Kinase)IBA 12/2019 - 01/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 07/2019 - 01/2017
2	LigandsIBA 01/2019 - 10/2016
2	EpitopesIBA 05/2018 - 01/2018
2	VaccinesIBA 05/2018 - 12/2015
2	Protein Subunit VaccinesIBA 05/2018 - 01/2018
2	LipopeptidesIBA 05/2018 - 01/2017
2	EnzymesIBA 01/2018 - 03/2016
2	LipidsIBA 01/2018 - 01/2014
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2017 - 02/2017
2	BL-EI001IBA 02/2017 - 03/2015
2	Folic Acid (Vitamin M)FDA LinkGeneric 12/2013 - 05/2013
2	monomethoxypolyethylene glycol (MPEG)IBA 05/2013 - 10/2012
2	Ethylene Glycol (Monoethylene Glycol)IBA 10/2012 - 04/2011
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022
1	GasotransmittersIBA 01/2022
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2022
1	HydrogenIBA 01/2022
1	AmmoniaIBA 01/2022
1	Sulfur DioxideIBA 01/2022
1	Carbon MonoxideIBA 01/2022
1	Casein Kinase II (Casein Kinase 2)IBA 12/2021
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2021
1	mouse glutathione peroxidase 4IBA 05/2021
1	OxindolesIBA 05/2021
1	MicroRNAs (MicroRNA)IBA 04/2021
1	pyrazoleIBA 01/2021
1	Monomeric GTP-Binding ProteinsIBA 01/2021
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 10/2020
1	KynurenineIBA 10/2020
1	spirooxindoleIBA 08/2020
1	Troponin IIBA 07/2020
1	Galectin 1 (LGALS1)IBA 01/2020
1	InflammasomesIBA 01/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2020
1	Hydroxamic Acids (Hydroxamic Acid)IBA 01/2020
1	AconitineIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	shikoninIBA 01/2020
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2019
1	Phosphatidylinositols (Phosphatidylinositol)IBA 12/2019
1	Indicators and Reagents (Reagents)IBA 10/2019
1	CurcuminIBA 10/2019
1	celastrolIBA 10/2019
1	Benzoyl Peroxide FDA LinkGeneric 07/2019
1	Forkhead Box Protein O1IBA 07/2019
1	afamelanotideIBA 07/2019

Therapy/Procedure

35	Therapeutics 01/2022 - 09/2010
4	Drug Therapy (Chemotherapy) 07/2019 - 06/2011
1	Operative Surgical Procedures 01/2020